(4) chemical pathways
short term memory:
neurotransmitter -->cAMP-->kinases-->potassium-->calcium-->glutamate
longterm memory:
neurotransmitter-->cAMP-->kinases-->CREB-->DNA-->mRNA+CPEB-->synaptic proteins
short term spatial memory/coincidence detector:
neurotransmitter-->NMDA-->calcium-->AMPA-->glutamate-->short-term map
longterm spatial memory/memory loss:
DA(age-related)-->cAMP(Rolipram)-->kinases (xAB peptide)-->CREBs+CPEB-->fixed map
emotional memory:
Amygdala: transmitter-->cAMP-->kinase-->CREB-->gastrin-releasing peptide: negative feedback
sensory-->hippocampus
depression:
no new nerve cells in dentate gyrus from transmitters
schizophrenic memory loss:
Excess D2 in striatum-->decrease in D1-->cAMP
emotional circuit (ledoux)
Sensory-->amygdala / sensory cortex-->hypothalamus / cingulate cortex
conscious circuit:
unconscious background fear-->amygdala